I am a bigger girl and i also have big breast (DDD). As to Sensativity mine are VERY sensative. More so than several women with smaller ones that i have met (but not all that i have met), so i would have to say the size doesn't matter about that.
As far as the losing weight thing, i am one of the unlucky few that do not lose breast when i lose weight. They stay right where they are, but if I gain weight they do get a little bigger.
Now for as far as getting them reduced, I would love to get mine done. I wouldn't mine then as much if they were perky, but i am not that lucky

. My mom had hers reduced and it helped her alot. Now this was over 15 yrs ago so i bet the surgery has gotten better now, but i do know recovery time for her was pretty long.
Hope this helps
Robin
PS I guess i am one of the lucky ones, my nipples are large also.