I've had several friends who were transitioning and in one case, transitioned. For me it's a no-brainer, if I'm attracted to them it doesn't matter what equipment they have or had.
I did get the opportunity to play a few years back with a friend who was transitioning MtF and I had to think long and hard whether I wanted to play with her or if it was just the novelty of the situation. In the end I did play with her and her female partner and it was fun