Mrs. Alura here:
On the semi-serious side.....I don't know what is going on in your lives.....I don't know if your wife has a high stress job.....I don't know if somebody's In-Laws are coming for the holidays.......
Perhaps you could ask your wife "Is there some way that I could help alleviate some of the stress in your life? Seriously, tell me what I can do."
If she asks "Why do you ask?" you might reply "You are not eating the way you usually do and that can be a response to stress. So, I was just wondering..."'
And then shut up.
Good Luck......and remember

the "Shut up" part. That's critical.
Smiles!
Mrs. Alura
P.S. You could give her sugar free chocolates for Christmas, and then again for Valentines. Check with your local gift shop. facelick